Endocrine Abstracts

Introduction: Pituitary adenomas are the most common pituitary tumours, but in 18% of cases we can find other rare tumours like: Rathke’s cleft cyst, craniopharingyomas, chordomas, meningiomas, infiltrative or infectious disease. Meningeal melanocytoma is a benign neoplasm of central nervous system, commonly located in the base of the brain, cerebellopontine angle and the pineal body, difficult to differentiate from a nonfunctional p...

Background: Differentiated thyroid cancer (DTC) encompases a wide spectrum of disease from clinically insignificant micro-tumors to aggressive cancers. The molecular signature can be used to predict tumor behaviour, and the co-existence of BRAF and TERT promoter mutations has been identified as a marker of adverse prognosis, but we have yet no available molecular data for the Romanian population.Objectives: To determine the prevalence of BRAF V600E and T...

Introduction: Bilateral pheochromocytomas (PHEOs) most often occur as components of hereditary syndromes: MEN2A, VHL disease or neurofibromatosis. The best surgical technique in such cases is yet disputed between cortical sparing or total adrenalectomy. Two important complications are related to each surgical technique: adrenal insufficiency (AI) or recurrence-which one is more harmful for the patient?Aim: To evaluate the complications (recurrence, AI) r...

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder caused by germline mutations of MEN1 gene, without genotype–phenotype correlation. It is defined as the occurrence of two or more primary neuroendocrine tumors (parathyroid, enteropancreatic, pituitary), or the occurrence of one of the MEN1-associated tumors in family members of a patient with a clinical diagnosis of MEN1. Multiple parathyroid tumors with hyperparathyroidism are the most common m...

Introduction: Pheochromocytomas (PHEOs) are tumors arising from medulla chromaffin cells. Their diagnosis is challenging due to a large clinical spectrum – from classical crisis to completely asymptomatic. Approximately 5.0–6.5% of adrenal incidentalomas are pheochromocytomas, and 8% of pheochromocytomas are completely asymptomatic, usually in a familial form.Aim: To compare biochemical and imagistic features of symptomatic/asymptomatic PHEOs.<...

Introduction: Hyperglycaemia occurs frequently in catecholamine-secreting tumours due to insulin suppression or induced insulin resistance. These changes can be reversible postoperatory (postOp).Objective: Our study aims to establish the impact of surgery in patients with catecholamine-secreting tumours upon glucose metabolism disorders, as well as the predictive factors for postOp diabetes-free patients.Methods: We retrospectively...

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor derived from the thyroid C cells producing calcitonin, ac-counts for 0.6% of all thyroid cancers. It occurs either sporadically or in a hereditary form (RET mutation). MTC can be cured only by complete resection of the thyroid tumor and any loco-regional metastases. Calcitonin (CT) measurement is crucial to the early diagnosis and the follow-up of MTC. If the evaluation of stimulated CT levels is required, a prov...

Abstract: Medullary thyroid cancer (MTC) is a highly aggressive neuroendocrine tumour originating in the thyroid parafollicular cells. Calcitonin measurement and RET gene ascertainment have been used as markers for early diagnosis of MTC. Since pentagastrin is not available, calcium stimulation test helps to preclude ‘gray zone’ values of basal calcitonin, diagnose minimal residual disease and help the early diagnosis of C cell hyperplasia.Aim:...

Giant prolactinoma it’s a very rare tumor that due to its massive extension into surrounding structures can present more often with neurological complications such as visual defects, cranial nerve paresis or even hydrocephalus, unlike the classic prolactinoma presentation with amenorrhea, infertility and galactorrhea. On CT/MRI exams it can present as aggressive skull base tumor and its immunohistochemistry (IHC) may have common features with neuroendocrine neoplasms....

Introduction: BRAF V600E mutation is reported to occur in 28–83% of papillary thyroid cancer, being associated with increased tumour aggressiveness.Objective: To determine the prevalence of BRAF V600E mutation in Romanian patients with thyroid nodules referred to surgery in a reference endocrinology centre.Materials and methods: 140 patients were included in the study: 70 patients with papillary thyroid carcinoma (PTC), 42 pat...